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Even in ancient instances people are unaware on the existence of living organisms invisible for the eye, causing illness. Thus, the ancient Greek scientist and doctor Hippocrates expressed this assumption in 1 of his works. But come to grips with their study of mankind has been able only soon after the Dutch optician van essay stone Leeuwenhoek in the XVI century made the initial microscope and saw firsthand the bacteria within a drop of water. Nonetheless, numerous in the class scientist denied the existence of pathogens within several centuries immediately after the invention of Leeuwenhoek.